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严格雪崩准则 3

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Organ function support in patients with coronavirus disease 2019: Tongji experience

Yong Li, Fan He, Ning Zhou, Jia Wei, Zeyang Ding, Luyun Wang, Peng Chen, Shuiming Guo, Binhao Zhang, Xiaoning Wan, Wei Zhu, on behalf of Multidisciplinary Team for COVID-19, Optical Valley Branch of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China

《医学前沿（英文）》 2020年第14卷第2期页码 232-248 doi: 10.1007/s11684-020-0774-9

摘要： Coronavirus disease 2019 (COVID-19) is a highly contagious disease and a serious threat to human health. COVID-19 can cause multiple organ dysfunction, such as respiratory and circulatory failure, liver and kidney injury, gastrointestinal dysfunction, disseminated intravascular coagulation, and thromboembolism, and even death. The World Health Organization reports that the mortality rate of severe-type COVID-19 is over 50%. Currently, the number of severe cases worldwide has increased rapidly, but the experience in the treatment of infected patients is still limited. Given the lack of specific antiviral drugs, multi-organ function support treatment is important for patients with COVID-19. To improve the cure rate and reduce the mortality of patients with severe- and critical-type COVID-19, this paper summarizes the experience of organ function support in patients with severe- and critical-type COVID-19 in Optical Valley Branch of Tongji Hospital, Wuhan, China. This paper systematically summarizes the procedures of functional support therapies for multiple organs and systems, including respiratory, circulatory, renal, gastrointestinal, hepatic, and hematological systems, among patients with severe- and critical-type COVID-19. This paper provides a clinical reference and a new strategy for the optimal treatment of COVID-19 worldwide.

关键词： COVID-19 severe and critical type organ function support

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Effects of elastic support on the dynamic behaviors of the wind turbine drive train

Shuaishuai WANG, Caichao ZHU, Chaosheng SONG, Huali HAN

《机械工程前沿（英文）》 2017年第12卷第3期页码 348-356 doi: 10.1007/s11465-017-0420-7

摘要：

The reliability and service life of wind turbines are influenced by the complex loading applied on the hub, especially amidst a poor external wind environment. A three-point elastic support, which includes the main bearing and two torque arms, was considered in this study. Based on the flexibilities of the planet carrier and the housing, a coupled dynamic model was developed for a wind turbine drive train. Then, the dynamic behaviors of the drive train for different elastic support parameters were computed and analyzed. Frequency response functions were used to examine how different elastic support parameters influence the dynamic behaviors of the drive train. Results showed that the elastic support parameters considerably influenced the dynamic behaviors of the wind turbine drive train. A large support stiffness of the torque arms decreased the dynamic response of the planet carrier and the main bearing, whereas a large support stiffness of the main bearing decreased the dynamic response of planet carrier while increasing that of the main bearing. The findings of this study provide the foundation for optimizing the elastic support stiffness of the wind turbine drive train.

关键词： wind turbine drive train elastic support dynamic behavior frequency response function

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用于器官芯片的工程化血管系统 Review

Abdellah Aazmi, 周竑钊, 李雨亭, 俞梦飞, 许晓斌, 吴钰桐, 马梁, 张斌, 杨华勇

《工程（英文）》 2022年第9卷第2期页码 131-147 doi: 10.1016/j.eng.2021.06.020

摘要：

器官芯片技术是一种很有前途的三维（3D）动态培养方法，可确保准确高效的细胞培养，在临床前试验中具有替代动物模型的巨大潜力。血管系统是人体内最丰富的器官，在氧气交换和物质传递中起着至关重要的作用，是组织器官生存的决定性因素。因此，必须将血管系统集成到器官芯片中，以重建组织和器官微环境及其生理功能。本文讨论了血管与新兴器官芯片技术之间的协同作用，为复现生理学和疾病特征提供了更好的可能性。此外，回顾了血管化的器官芯片制造过程的不同步骤，包括使用不同生物制造策略的结构制造和组织构建。最后，概述了这项技术在器官和肿瘤培养这个有极具吸引力且快速发展的领域的适用性。

关键词：器官芯片血管生物打印肿瘤芯片

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A literature review of perishable medical resource management

《工程管理前沿（英文）》页码 710-726 doi: 10.1007/s42524-023-0278-9

摘要： In recent decades, healthcare providers have faced mounting pressure to effectively manage highly perishable and limited medical resources. This article offers a comprehensive review of supply chain management pertaining to such resources, which include transplantable organs and healthcare products. The review encompasses 93 publications from 1990 to 2022, illustrating a discernible upward trajectory in annual publications. The surveyed literature is categorized into three levels: Strategic, tactical, and operational. Key problem attributes and methodologies are analyzed through the assessment of pertinent publications for each problem level. Furthermore, research on service innovation, decision analytics, and supply chain resilience elucidates potential areas for future research.

关键词： perishable medical resources organ transplant healthcare products decision analytics operations management

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舰船综合保障系统设计

祝泓,张平

《中国工程科学》 2015年第17卷第5期页码 44-50

摘要：

本文在分析国外综合保障系统的基础上，提出了适用于我国舰船的保障系统顶层设计方案，给出了系统组成、主要功能和主要技术指标，将综合保障系统划分为保障资源系统、装备综合保障管理信息系统、装备故障诊断与健康管理系统三个分系统，并对各分系统的系统功能和组成进行了阐述，为舰船装备开展综合保障系统集成和管理提供了参考。

关键词：舰船综合保障系统系统设计保障资源

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Piezoelectric pump with flexible venous valves for active cell transmission

《机械工程前沿（英文）》 2022年第17卷第4期 doi: 10.1007/s11465-022-0712-4

摘要： The development of organ-on-a-chip systems demands high requirements for adequate micro-pump performance, which needs excellent performance and effective transport of active cells. In this study, we designed a piezoelectric pump with a flexible venous valve inspired by that of humans. Performance test of the proposed pump with deionized water as the transmission medium shows a maximum output flow rate of 14.95 mL/min when the input voltage is 100 V, and the pump can transfer aqueous solutions of glycerol with a viscosity of 10.8 mPa·s. Cell survival rate can reach 97.22% with a yeast cell culture solution as the transmission medium. A computational model of the electric-solid-liquid multi-physical field coupling of the piezoelectric pump with a flexible venous valve is established, and simulation results are consistent with experimental results. The proposed pump can help to construct the circulating organ-on-a-chip system, and the simple structure and portable application can enrich the design of microfluidic systems. In addition, the multi-physical field coupling computational model established for the proposed piezoelectric pump can provide an in-depth study of the characteristics of the flow field, facilitating the optimal design of the micro-pump and providing a reference for the further study of active cell transport in organ-on-a-chip systems.

关键词： venous valve flexible venous valve cell transmission organ-on-a-chip system piezoelectric device

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Socialized care services for the aged population: System construction and support measures

《工程管理前沿（英文）》 2023年第10卷第2期页码 339-353 doi: 10.1007/s42524-022-0208-2

摘要： Given the aging society, an increase in social demand, information- and communication technology-driven culture, and government policy support emerges to enable the development of the socialized care services system for the aged (SCSSA). The development of the SCSSA would be a significant step toward addressing China’s aging population. However, the construction of the SCSSA challenges the theories and methods of traditional elderly care service system construction. Specifically, the implementation path for such elderly care service policies is unclear, the necessary technological support is insufficient, and the mechanism for integrating intelligent information technology remains underexplored. Thus, this paper focuses on the needs of the elderly, grounded in the context of the changing elderly care service policies in China, and proposes a research paradigm that integrates system construction and support measure embedding. We then construct the original SCSSA, which includes “material + spirit + medical treatment + healthcare” and propose a method of optimization and iteration. Finally, we build the research framework of systematic support measures from the perspectives of policy reconstruction, institutional embeddedness, and technical support. Our work provides theoretical support and practical guidance for the construction and dynamic optimization of the SCSSA, thus making a significant contribution that will help China effectively cope with its aging society.

关键词： socialized care service for the elderly system construction support measure

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BMP decision support system for evaluating stormwater management alternatives

Mow-Soung CHENG, Jenny X. ZHEN, Leslie SHOEMAKER,

《环境科学与工程前沿（英文）》 2009年第3卷第4期页码 453-463 doi: 10.1007/s11783-009-0153-x

摘要： Prince George’s County, Maryland, in the Washington D.C. metropolitan area has developed a best management practice decision support system (BMPDSS) to support analysis and decision making for stormwater management planning and design at both the site scale and the watershed levels. This paper presents a detailed description of the BMPDSS. A case study that demonstrates the application of the system is also included. The case study involves a Green Highway project located in a highly urbanized area within the Anacostia River watershed of the county. Several best management practices (BMP) such as bioretention, filter vegetative swale, porous paving, and landscape infiltration are proposed for reducing highway runoff and improving water quality. The BMPDSS is used to identify and evaluate various alternatives to determine the most cost-effective types and combinations of BMPs that minimize the highway runoff pollution.

关键词： best management practices decision support system low impact development geographic information system optimization

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Emerging roles of podoplanin in vascular development and homeostasis

null

《医学前沿（英文）》 2015年第9卷第4期页码 421-430 doi: 10.1007/s11684-015-0424-9

摘要：

Podoplanin (PDPN) is a mucin-type O-glycoprotein expressed in diverse cell types, such as lymphatic endothelial cells (LECs) in the vascular system and fibroblastic reticular cells (FRCs) in lymph nodes. PDPN on LECs or FRCs activates CLEC-2 in platelets, triggering platelet activation and/or aggregation through downstream signaling events, including activation of Syk kinase. This mechanism is required to initiate and maintain separation of blood and lymphatic vessels and to stabilize high endothelial venule integrity within lymph nodes. In the vascular system, normal expression of PDPN at the LEC surface requires transcriptional activation of Pdpn by Prox1 and modification of PDPN with core 1-derived O-glycans. This review provides a comprehensive overview of the roles of PDPN in vascular development and lymphoid organ maintenance and discusses the mechanisms that regulate PDPN expression related to its function.

关键词： podoplanin CLEC-2 Prox1 O-glycosylation lymphatic vascular development and maintenance lymphoid organ homeostasis

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Liquefaction prediction using support vector machine model based on cone penetration data

Pijush SAMUI

《结构与土木工程前沿（英文）》 2013年第7卷第1期页码 72-82 doi: 10.1007/s11709-013-0185-y

摘要： A support vector machine (SVM) model has been developed for the prediction of liquefaction susceptibility as a classification problem, which is an imperative task in earthquake engineering. This paper examines the potential of SVM model in prediction of liquefaction using actual field cone penetration test (CPT) data from the 1999 Chi-Chi, Taiwan earthquake. The SVM, a novel learning machine based on statistical theory, uses structural risk minimization (SRM) induction principle to minimize the error. Using cone resistance ( ) and cyclic stress ratio ( ), model has been developed for prediction of liquefaction using SVM. Further an attempt has been made to simplify the model, requiring only two parameters ( and maximum horizontal acceleration ), for prediction of liquefaction. Further, developed SVM model has been applied to different case histories available globally and the results obtained confirm the capability of SVM model. For Chi-Chi earthquake, the model predicts with accuracy of 100%, and in the case of global data, SVM model predicts with accuracy of 89%. The effect of capacity factor ( ) on number of support vector and model accuracy has also been investigated. The study shows that SVM can be used as a practical tool for prediction of liquefaction potential, based on field CPT data.

关键词： earthquake cone penetration test liquefaction support vector machine (SVM) prediction

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Current applications of artificial intelligence for intraoperative decision support in surgery

Allison J. Navarrete-Welton, Daniel A. Hashimoto

《医学前沿（英文）》 2020年第14卷第4期页码 369-381 doi: 10.1007/s11684-020-0784-7

摘要： Research into medical artificial intelligence (AI) has made significant advances in recent years, including surgical applications. This scoping review investigated AI-based decision support systems targeted at the intraoperative phase of surgery and found a wide range of technological approaches applied across several surgical specialties. Within the twenty-one ( =21) included papers, three main categories of motivations were identified for developing such technologies: (1) augmenting the information available to surgeons, (2) accelerating intraoperative pathology, and (3) recommending surgical steps. While many of the proposals hold promise for improving patient outcomes, important methodological shortcomings were observed in most of the reviewed papers that made it difficult to assess the clinical significance of the reported performance statistics. Despite limitations, the current state of this field suggests that a number of opportunities exist for future researchers and clinicians to work on AI for surgical decision support with exciting implications for improving surgical care.

关键词： artificial intelligence decision support clinical decision support systems intraoperative deep learning computer vision machine learning surgery

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Reliability-based design optimization of offshore wind turbine support structures using RBF surrogate

《结构与土木工程前沿（英文）》页码 1086-1099 doi: 10.1007/s11709-023-0976-8

摘要： Reliability-based design optimization of offshore wind turbine support structures using RBF surrogate model

关键词： RBF surrogate model turbine support structures

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创造力支持系统的体系结构研究

梁志成,于跃海,仲伟俊

《中国工程科学》 2010年第12卷第1期页码 74-80

摘要：

介绍了创造力支持系统发展历程、创造力与创造性思维，综合研究了各类创造力支持系统，给出了创造力支持系统的构成要素、体系结构，并以构建系统用于电力系统故障分析实例研究，阐述了创造力支持系统对专家思维的支持过程。为创造力支持系统开发实现与应用提供参考。

关键词：创造力支持系统体系结构群体研讨环境表决链表

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ENABLING CROP DIVERSIFICATION TO SUPPORT TRANSITIONS TOWARD MORE SUSTAINABLE EUROPEAN AGRIFOOD SYSTEMS

《农业科学与工程前沿（英文）》 2021年第8卷第3期页码 474-480 doi: 10.15302/J-FASE-2021406

摘要：

European cropping systems are often characterized by short rotations or even monocropping, leading to environmental issues such as soil degradation, water eutrophication, and air pollution including greenhouse gas emissions, that contribute to climate change and biodiversity loss. The use of diversification practices (i.e., intercropping, multiple cropping including cover cropping and rotation extension), may help enhance agrobiodiversity and deliver ecosystem services while developing new value chains. Despite its benefits, crop diversification is hindered by various technical, organizational, and institutional barriers along value chains (input industries, farms, trading and processing industries, retailers, and consumers) and within sociotechnical systems (policy, research, education, regulation and advisory). Six EU-funded research projects have joined forces to boost crop diversification by creating the European Crop Diversification Cluster (CDC). This Cluster aggregates research, innovation, commercial and citizen-focused partnerships to identify and remove barriers across the agrifood system and thus enables the uptake of diversification measures by all European value-chain stakeholders. The CDC will produce a typology of barriers, develop tools to accompany actors in their transition, harmonize the use of multicriteria assessment indicators, prepare policy recommendations and pave the way for a long-term network on crop diversification.

关键词： crop rotation lock-in intercropping multiple cropping networking

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关于3D打印技术在医学模具以及再生组织和器官方面的应用综述

Kan Wang, Chia-Che Ho, Chuck Zhang, Ben Wang

《工程（英文）》 2017年第3卷第5期页码 653-662 doi: 10.1016/J.ENG.2017.05.013

摘要：

医学模型或模具已广泛应用于医学培训和医患互动领域，同时也日益应用于手术规划、医学计算模型、算法核实和验证以及医疗器械的开发等方面。这种新应用需要高保真度、患者特异性及模拟组织结构的医学模具，其不仅能够模拟人体器官的几何结构，而且还具有器官的功能。随着三维（3D）打印和3D 生物打印技术的快速发展，许多研究人员已经开始使用增材制造技术来生产具有多种功能的医学模具。本文综述了3D 打印和3D 生物打印技术在制作功能性医学模具和生物结构方面的应用。特别讨论了3D 打印功能性医学模具（即组织模拟医学模具、放射性医学模具和生理医学模具）及被用于再生组织和器官的3D 生物打印模具的制备（即混合模式支架材料、可转换支架和集成传感器）工艺、发展现状以及未来发展趋势。

关键词： 3D打印 3D生物打印医学模具再生组织/器官支架